Transnational Call

MEDICINAL CHEMISTRY

 

Medicinal Chemistry Call

Successful screening campaigns from the small molecule screening call can apply for one of five chemical optimisation projects at our EU-OPENSCREEN ERIC chemistry partner sites. This call will be launched in 2021 and this website will be updated in due time with more details.

The starting point will be a set of validated primary hits coming from the preceding small molecule screening call. The five chemical optimization projects will cover the following:

  • Searching structure/activity landscape around validated primary hits in databases including patents to ensure novelty for the observed target-related or disease-model related activities
  • Assessment of individual validated primary hits regarding their potential for directed chemical modification
  • Recommendation of commercially available analogues for initial SAR characterization
  • Chemical modifications of validated hits for improvement of specificity, activity and pharmacological properties (i.e. chemical synthesis)
  • Iterative re-screening of the respective biological assay for improved properties using chemically modified hits (done in close collaboration with the user and the respective EU-OS screening partner)
 

The following five institutions will offer their medicinal chemistry expertise under this call:

Masaryk University, Department of Chemistry - orgsyn.sci.muni.cz

Leibniz-Forschungsinstitut für Molekulare Pharmakologie - www.fmp-berlin.de/nazare

Technical University of Denmark (DTU), Department of Chemistry - www.kemi.dtu.dk/english/research/organic-inorganic-chemistry/kemisk_biologi/madshclausenintro

Centro de Investigaciones Biológicas (CSIC), Translational Medicinal and Biological Chemistry - cib.csic.es/research/structural-and-chemical-biology/translational-medicinal-and-biological-chemistry

Latvian Institute of Organic Synthesis - www.osi.lv