Transnational Call



Medicinal Chemistry Call 2021

Successful screening campaigns from the small molecule screening call can apply for one of five chemical optimisation projects at our EU-OPENSCREEN ERIC chemistry partner sites. This call will be launched in 2021 and this website will be updated in due time with more details.

The starting point will be a set of validated primary hits coming from the preceding small molecule screening call. The five chemical optimization projects will cover the following:

  • Searching structure/activity landscape around validated primary hits in databases including patents to ensure novelty for the observed target-related or disease-model related activities
  • Assessment of individual validated primary hits regarding their potential for directed chemical modification
  • Recommendation of commercially available analogues for initial SAR characterization
  • Chemical modifications of validated hits for improvement of specificity, activity and pharmacological properties (i.e. chemical synthesis)
  • Iterative re-screening of the respective biological assay for improved properties using chemically modified hits (done in close collaboration with the user and the respective EU-OS screening partner)

The following five institutions will offer their medicinal chemistry expertise under this call:

Masaryk University, Department of Chemistry -

Leibniz-Forschungsinstitut für Molekulare Pharmakologie -

Technical University of Denmark (DTU), Department of Chemistry -

Centro de Investigaciones Biológicas (CSIC), Translational Medicinal and Biological Chemistry -

Latvian Institute of Organic Synthesis -